ABSTRACT
Objective To investigate the influence of conventional and high dose of interferon atomization inhalation on the short-term clinical efficacy,lung function and adverse effects of children with bronchiolitis.Methods 160 children with bronchiolitis were chosen and randomly divided into two groups,80 cases in each group.On the basis of salbutamol inhalation,A group was given recombinant interferon α-2b for 200 000 IU · kg-1 · d-1,and B group was given recombinant interferon α-2b for 400 000 IU · kg-1 · d-1.The short-term clinical efficacy,the disappeared time of symptoms and signs,the hospital staying time,the disease severity score,the levels of RR and SpO2 before and after treatment and the incidence of adverse effects were compared between the two groups.Results The excellence effects and total clinical effects of B group were significantly higher than those of A group(x2 =7.27,P ＜ 0.05).The disappeared time of symptoms and signs and hospital staying time of B group were significandy shorter than those of A group(t =2.78,2.65.3.04,2.19,all P ＜ 0.05).Mter treatment,the disease severity scores of B group were significantly lower than those of A group and before treatment(t =2.43,2.13,2.55,2.07;3.02,3.41;3.11,3.65;2.81,3.30;2.87,3.15;all P ＜ 0.05).After treatment,the indicators of pulmonary ventilation function of B group were significantly lower than those of A group and before treatment(t =2.35,2.20,2.73,3.04;2.49,2.97,all P ＜ 0.05).There was no statistically significant difference in the incidence rate of adverse effects between the two groups(x2 =1.26,P ＞ 0.05).Conclusion Compared with conventional dose of interferon,high dose interferon atomization inhalation in the treatment of children with bronchiolitis can effectively higher the disease control effects,speed up the disease rehabilitation process,improve the pulmonary ventilation function and without aggravate drug adverse reactions.